.Net 4.5, how to change zone security settings via .NET Framework configuration

.Net 4.5, how to change zone security settings via .NET Framework
configuration

In .net 1.1 we could do something like:
Go to "Control panel" in the Windows Start menu.
Select "Administrative Tools" (double click)
Select "Microsoft .NET Framework Configuration"
Click "Configure Code Access Security Policy"
Click "Adjust Zone Security"
Check "Make changes to this computer" and click next.
Select "Local Intranet", move settings to "Full trust" and click next.
Click "Finish" and close the window with "Microsoft .NET Framework
Configuration"
How do we achieve this on a machine with 4.5?